ABSTRACT
Inflammatory myofibroblastic tumor [IMT] is a tumor composed of myofibroblasts and a mixed inflammatory infiltrate that rarely undergoes malignant transformation. The most common sites of involvement include the lung, liver and orbit, but it has been reported to occur in nearly every site of the body, including oral cavity and soft tissue. Although common in other sites, such a tumor in rarer location including inguinal region is likely to be missed/misdiagnosed and hence need to be reported. We present an unusual case of a 50 year old male with bilateral inguinal swelling attended our institute few days back with history of local excision twice, but still showing recurrence. He was treated by wide local excision with bilateral orchiectomy this time. Histopathological report revealed inflammatory myofibroblastic tumor with malignant transformation. Adjuvant radiotherapy was also given and patient taken in followup. At one year of serial follow-ups, the patient is disease-free both clinically and on investigations, indicating successful combined surgery and radiotherapy in the treatment of malignant IMT. IMT of the inguinal region is very rare. Its clinical presentation may resemble malignant tumor, so IMT should be kept as differential diagnosis. The recommended treatment is complete surgical resection with adjuvant corticosteroid. Adjuvant radiotherapy may be considered depending upon the location of the tumor
ABSTRACT
Present paper deals with the study of therapeutical potential of aqueous extract of leaves, seeds and stem bark of certain drug plants like Ocimum sanctum, Piper nigrum and Ficus religiosa against certain bactcrial species i.e., Escherichia coli and Bacillus subtilis separately in vitro in terms of inhibitory effect. A treatment of combined mixture of all the three extracts at different ratios i.e., 1: 1: 1, 1: 1: 2, 1: 2: 1 and 2: 1: 1 of O. sanctum, P. nigrum and F. religiosa was also done to find out variability of potency in vitro. Results revealed that maximum inhibition zone was recorded against extract of O. sanctum against both bacterial species [E. coli and B. subtilis] followed by P. nigrum and F. religiosa. A trend of enhancement of therapeutic potency [efficacy] was noted with an increase of amount of drug extract [in terms of ml.] and showed positive line of correlation with unit of drug extract and efficacy. The mixture of different ratios of O. sunctum, P. nigrum and F. religiosa showed maximum drug efficacy against both bacterial species at ratio of 1: 2: 1 [where 02 for P. nigrum] and 2: 1: 1 [where 2 for O. sanctum. Minimum drug efficacy was recorded at ratio 1: 1: 1. The treatment of bacterial strains with combined mixture showed better efficacy in both species as compared with separate treatment in general. The compound extract treatments were much encouraging and have given a new direction in the field of herbal therapeutics for the researchers to work in this area